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sturdy CYP3A Inhibitors XANAX is contraindicated in people receiving potent inhibitors of CYP3A (which include azole antifungal brokers), besides ritonavir [see Contraindications (four)]. Ketoconazole and itraconazole are actually revealed in vivo to extend plasma alprazolam concentrations 3. Interactions involving ritonavir and alprazolam are sop